Migraine sufferers could have their headaches switched off after researchers discovered a gene that acts like a pain thermostat in the brain.
- Enjoy this article? Help vote it up the 'Vine.
- Public Discussion (9)
The "once in a generation" finding could allow scientists to create a new generation of drugs that can simply turn down up the theshold at which the body fells pain.
The international study, including scientists at Oxford University, found that a gene called TRESK appears to be fundamental in causing migraines.
It is believed that it controls the sensitivity of pain nerves in the brain and if faulty can bring the threshold so low that just living is painful.
This is why migraine sufferers are so sensitive to light, sounds and even touch.
But the gene is also susceptible to being switched on and off with drugs which means that it could be altered to increase the threshold to such an extent it eliminates the feeling of pain altogether.
"We are really excited about this," said Dr Zameel Cader, a consultant neurologist at the Medical Research Council Functional Genomics Unit at the University of Oxford.
"It is a once in a generation find that could one day lead to treatments that could prevent migraines. Potentially it is even more exciting than that.
"It could potentially lead to a treatment for pain in general. That could impact everybody."
- 3 votes
This is good news! I have had migraines before, and it was horrible...it made me sicker than a dog...
- 3 votes
The only drawback I could see is the same thing as a labotomy; masking the symptoms. ("I'd rather have a bottle in front of me than a frontal labotomy!") True, with migraines, there is no known cause for many. Could be hormones, could be caffeine, could be stress. I know with my wife, red wine causes migraines. She used to get them monthly, but not in sync with her periods. Could menstruation chemically actually be an ongoing process throughout the month? I've read of people who couldn't feel pain. They would burn themselves, or cut themselves badly, and not know it for days if no one was around, or they didn't see it. Some die from systemic infections because of the lack of pain response. I do remember racing along driving my wife to the hospital as she hangs her head out the window, screaming and vomiting all over the side of the car. I would have given both my arms and feet to relieve her of that torment. We men are fixers, and to be utterly powerless when the one you love is in excruciating agony...I can well understand the attraction to just shut it off. Methinks there would need to be safeguards in place. For example, the family doctor, who knows the history, can be the only one to administer the shut-off. And this creates another problem if you decide to go backpacking around Europe for six months. Doc would have to be available by phone 24/7.
- 1 vote
You have brought up some interesting questions here...
This could mask the real reason a person has pain, which could be a bad thing...if there is a disease involved that the person needs treated for, and the symptoms are masked, the person could be in real trouble...
My son has a very high pain tolerance. Things that would bring me to my knees get barely a nod from him, which is hard for me to understand! He had a broken foot once, and I had no idea anything was wrong until three days after he first limped at school and the teacher asked him if something was wrong...I was shocked at how he barely whimpered over the pain.
Now me? Well all I can say is, if I am in pain, please shut off my pain thermostat! I promise I will be very careful and not do anything stupid, lol:))
- 2 votes
Oh, and if any of you are migraine sufferers, what my wife and I found that actually worked was Toradol. It's spendy, and not on the list of drugs for which doctors get sent on all expense paid junkets to the Bahamas by drug companies. But push your doctor for it, and try it. Remember, your doctor works for you. They aren't doing you a favor by letting you come to them. And having said that, I must tell you a story:
My wife has fibromyalgia and Chronic Fatigue Syndrome, as well as a whole list of satellite illnesses that leave her mostly bed-ridden, and in pain. Back around 1993 she began to have a pain in her lower abdomen, which they decided was pre-cancerous polyps on her one remaining ovary. The doctor that first saw her told her that he didn't believe fibromyalgia was a real disease, and was all in the patient's head. My wife came out of the appointment in tears, and told me what he said. I marched up to this doctor, and right in front of everyone, told him that he needed to update his knowledge of medicine, and since he can't seem to grasp recent discoveries and verifications, then we have no use for him. And I told him he was fired. One thing I hate is arrogance. That's something that gets my juices flowing..ooooh.... He called the next day and told me that he had done some studying during the night, and said that he believes fibromyalgia to be a valid disease, and he apologized. And that's the thing with me, if you act like a fool, but later realize you acted like a fool, and you genuinely apologize, the storm clouds break and go away and the blue sky and sunshine come out and all is right with the world. Such is the nature of accepting an apology. I actually really like apologies. I hate conflict. Anyway...
If you have insurance, they cover Toradol. The pills are 10mg, and she would take one at the onset of a migraine. If in one hour it didn't go away, she would take a second. Of course, this hour is spent in a darkened room with quiet and a cool washcloth on her forehead. We went from monthly visits to the hospital, to three years between having to get a shot of demerol. Toradol...a Godsend. And she never took more than the second one. Actually, after three years, we had to go the hospital because the second one didn't work. The next time she had a migraine after that, the first one worked. Go figure. She doesn't get migraines any more. Perhaps they're overshadowed by the chronic sinus infection.
- 1 vote
Bonnie, I knew soldiers that would drive on with stress fractures in their feet. When we went into Panama, our company commander and first seargeant both broke a leg parachuting into Rio Hato. They remained on duty with the troops, riding around on a couple of confiscated three wheelers for four days, before being medevac'd out. I chalked it up to stupidity. Pain is our body's way of telling us the machinery is broken, or in the process of breaking. Methinks we listen not at our peril.
- 2 votes
You're in Easy Mode. If you prefer, you can use XHTML Mode instead. |



